The control of paracetamol particle size and surface morphology through crystallisation in a spray dryer

The parameters governing the crystallisation of paracetamol using various conventional techniques has been extensively studied, however the factors influencing the drug crystallisation using spray drying is not as well understood. The aim of this work was to investigate the crystallisation of an active pharmaceutical ingredient through evaporative crystallisation using a spray dryer to study the physicochemical properties of the drug and to use semi-empirical equations to gain insight into the morphology and particle size of the dried powder. Paracetamol solutions were spray dried at various inlet temperatures ranging from 60 °C to 120 °C and also from a series of inlet feed solvent compositions ranging from 50/50% v/v ethanol/water to 100% ethanol and solid-state characterisation was done. The size and morphology of the dried materials were altered with a change in spray drying parameters, with an increase in inlet temperature leading to an increase in particle Sauter mean diameter (from 3.0 to 4.4 µm) and a decrease in the particle size with an increase in ethanol concentration in the feed (from 4.6 to 4.4 µm) as a result of changes in particle density and atomised droplet size. The morphology of the dried particles consisted of agglomerates of individual crystallites bound together into larger semi-spherical agglomerates with a higher tendency for particles having crystalline ridges to form at higher ethanol concentrations of the feed.     

高瓦斯矿井回采工作面瓦斯综合抽采技术实践

为了解决高瓦斯矿井工作面瓦斯涌出量大、瓦斯浓度高,制约工作面安全生产的问题,以亨元煤业为背景,结合矿井开采及瓦斯地质条件,确定了本煤层顺层钻孔抽采、穿层钻孔抽采邻近层和覆岩裂隙带瓦斯、以及对上隅角布置抽采管路进行抽采的综合治理方法。试验表明,工作面开采期间瓦斯涌出正常,上隅角瓦斯浓度保持在0.56%以下,实现了工作面安全高效开采。     

井下安全阀力学性能分析

井下安全阀对安全性和可靠性要求较高。以渤海油田常用油管携带式井下安全阀为分析对象,对其工作压力、地面控制压力、全开启和全关闭压力、最大下入深度和自平衡能力等关键力学性能进行分析。井下安全阀的工作压力值与地面液控压力值相等,其选取依据为井口压力; 全开启和全关闭液控压力值可通过压力曲线法得到; 最大下入深度取决于弹簧安装时的预紧力; 自平衡能力与活塞面积和自平衡孔面积的比值有关,比值越大,自平衡能力越强。     

第七届世界军人运动会核与辐射风险评估与控制

武汉市涉核单位众多,存在一定的核与辐射事故风险。通过对武汉市举办第七届世界军人运动会可能存在的核与辐射风险因素进行识别及评价,确定可能发生的12类核与辐射事故类型及风险水平,进而有针对性的制定风险防控措施,做到辐射应急管理关口前移,在保证军运会期间核技术利用单位正常生产活动的基础上有效的保障了核与辐射安全。     

MSCT多期增强扫描在肾脏透明细胞癌中的诊断价值

目的探讨多排螺旋CT(MSCT)多期增强扫描在肾脏透明细胞癌诊断中的规律性,提高对该肿瘤诊断水平。方法回顾性分析2016年1月~2018年6月14例均经手术切除病理证实为肾脏透明细胞癌患者的CT影像资料,所有病例均行MSCT平扫及多期动态增强扫描。结果14例肾脏透明细胞癌形态大多数呈圆形或者类圆形,瘤体最大径范围1.7cm^11.3cm,平均(4.8±1.4)cm,13例CT平扫时肿瘤密度不均匀,呈等低密度,1例呈等密度;12例出现坏死囊变,钙化1例,伴肾盂、肾盏侵犯2例;动态增强扫描可见12例包膜完整,1例均匀性强化,13例不均匀性强化;引入对比剂后皮质期,出现10例病灶强化幅度大于肾皮质,而仅4例低于肾皮质,三期平均CT值分别为110±30Hu,90±15Hu及75±14Hu,其中在实质期出现13例肿瘤强化幅度小于肾实质,仅1例大于肾实质。结论引入对比剂动态增强扫描后,肾脏透明细胞癌在皮质期明显不均匀强化,实质期强化幅度下降显著,呈现出典型的“快进快出”血流动力学强化方式,且肿瘤容易出现坏死、囊变为其特点。     

金沙江上游水电站应对白格堰塞湖灾害的措施及经验

2018年10月、11月,西藏自治区昌都市江达县白格村两次发生山体滑坡造成金沙江断流并形成白格堰塞湖,给金沙江上游沿岸人民生产生活设施造成巨大安全威胁和超过百亿元的经济损失。华电金沙江上游水电开发有限公司组织所属企业及参建单位快速应对,采取撤离避让、工程防护、人工干预、生产恢复,推动后续处置、风险评估等措施,最大限度减轻了对金沙江上游叶巴滩、拉哇、巴塘、苏洼龙等在建水电站的灾害损失和后续影响,为类似灾害的处置提供借鉴经验。     

Visually deficient working conditions and reduced work performance in office workers: Is it mediated by visual discomfort?

IntroductionThe main purpose of this cross-sectional study was to investigate whether visual discomfort acts as a mediating factor between perceived visual ergonomic working conditions and self-rated visual performance among office workers who carry out administrative tasks and computer-based work at the Swedish Tax Agency.MethodsA questionnaire was sent to 94 office workers addressing: 1) perceived visual quality of the visual display units; 2) prevalence of eye symptoms; and 3) self-rated visual performance. Eighty-six persons (54 women (63%), 31 men (36%), and 1 of unspecified sex) answered the questionnaire. Multiple regression analysis investigated the association between visual ergonomic working conditions and visual performance, both with and without visual discomfort as a mediator.ResultsThe group mean of the Indexed survey questions indicated a reasonably good quality of visual ergonomic working conditions, a relative absence of eye symptoms, and acceptable self-rated visual performance. Results from multiple regression analysis showed a significant association between perceived visual ergonomic working conditions and self-rated visual performance (r² = 0.30, β = 0.327, p < 0.01). When visual discomfort was used as a mediator, the association between perceived visual ergonomic working conditions and self-rated visual performance remained the same (r² = 0.32, β = 0.315, p < 0.01).DiscussionIt was remarkable to discover that self-rated visual performance was independent of visual discomfort. Possible explanations include exposure factors not included in the current study, such as dry air and sensory irritation in the eyes, psychosocial stress, time spent performing near work activities, or time exposed to visually deficient working conditions.Relevance to industryThe strong connection between satisfaction with visual ergonomic working conditions and productivity in this study has implications for workplace profitability and staff satisfaction. If productivity is enhanced by better visual ergonomic working conditions, then managers of workplaces may be able to improve work outcomes by optimizing the physical work environment.     

南水北调中线水源区浮游植物群落结构 及其生物多样性

为探究南水北调中线水源区丹江口水库浮游植物群落结构变化及其生物多样性，于 2014—2015 年对丹江 口水库进行为期 1 年的调查和分析。发现浮游植物共 8 门 76 属 101 种，其中，绿藻门、蓝藻门及硅藻门占总种数 90.10%，绿藻门种类数最多（45 种），其次是蓝藻门（26 种）和硅藻门（20 种）。浮游植物群落结构随季节变化有所 不同：夏秋季节生物量明显高于冬春季节；优势种在冬季以颗粒直链藻、颗粒直链藻极狭变种、铜绿微囊藻和小 环藻为主，春季以球衣藻、薄甲藻属及小环藻为主，夏季以简单颤藻、单胞衣藻原变种和球衣藻为主，秋季以类颤 藻鱼腥藻、简单颤藻、球衣藻和小环藻为主。应用 Shannon-Wiener 多样性指数 H′、Pielou 均匀度指数 J′、Margalef 丰富度指数 Dm评价水质结果表明：丹江口水库夏秋季水体营养化程度更高。典型对应分析表明：水温、透明度、 总氮、总磷等是影响浮游植物群落结构的主要环境因子，夏秋季受温度影响蓝藻、绿藻数量逐渐增多，一定程度 上增加了受水区生态变化风险。本研究可为南水北调中线水源区丹江口水库生态环境变化及生物迁移风险提供 数据支持。     

自动多功能可调式便老轮椅的设计

针对老年人群体设计一种自动可调式轮椅，轮椅靠背通过不完全齿轮机构进行自动调整。靠背竖起可作为普通轮椅使用；靠背放平可实现平躺，可通过靠背和座椅安置的滚轴实现从轮椅到床和沙发等位置的移动。该轮椅工作稳定，性能可靠，功能实现效果较好。